Orlando To Key West Road Trip: Best Routes & Stops!

The east coast route of the Orlando to Key West road trip takes you along US-1 and is the shorter of the two routes.

At about 400 miles, this journey takes about 6 to 7 hours to complete at a stretch.

But there are several great stops along the way that are worth visiting and worth extending the journey for.

And while the east coast route is shorter compared to the west coast route, it is worth noting that it goes through bustling cities which could mean traffic delays, making your travel time much longer.

The major cities and towns on the east coast route of this epic Florida road trip include West Palm Beach, Pompano Beach, Fort Lauderdale, Hollywood, and Miami.

Throughout the journey on this Orlando to Key West road trip, you will mainly be driving on signposted highways which are easy to drive on, and have all basic amenities like gas stations, EV charging stations, hotels, and even a few campgrounds along the way.

There are quite a few toll plazas as well along this way, especially around Kissimmee, Three Lakes, and Palm Beach.

1. Walt Disney World Resort, Orlando

While you are already in Orlando, why not make the most of this trip by visiting some of Orlando’s most iconic stops first before heading down south the Key West, yeah?

Visiting the Walt Disney World Resort in Orlando is a magical experience for children and adults alike.

Spanning over 25,000 acres, this iconic destination boasts four theme parks – Magic Kingdom, Epcot, Disney’s Hollywood Studios, and Disney’s Animal Kingdom – each offering a captivating realm of rides, attractions, and beloved characters.

The Resort’s attention to detail, from Cinderella’s Castle to futuristic pavilions, dazzling parades, fireworks displays, and live shows, all create an immersive atmosphere.

Whether you’re soaring through space, dining with princesses, or embarking on a safari, Walt Disney World Resort weaves dreams into reality, leaving an indelible mark and creating treasured memories that last a lifetime!

2. Universal Studios Florida, Orlando

Universal Studios Florida in Orlando is an exhilarating realm of cinematic thrills and immersive entertainment.

This dynamic theme park invites visitors to step into the movies, where iconic characters and blockbuster adventures come to life.

From heart-pounding rides like “Harry Potter and the Escape from Gringotts” to high-energy shows like “The Blues Brothers,” the park offers a tapestry of experiences spanning multiple genres.

The Wizarding World of Harry Potter transports fans to the enchanting realm of Hogwarts and Diagon Alley, while cutting-edge technology makes attractions like “Transformers: The Ride-3D” and “Race Through New York Starring Jimmy Fallon” a sensory marvel.

With its vibrant atmosphere, Hollywood-inspired streetscapes, and a mix of live shows and state-of-the-art simulations, Universal Studios Florida might just be that kick you need for an exciting journey ahead!

3. Kennedy Space Center, Merritt Island

If you are a science or space fanatic, or traveling with kids, the Kenedy Space Center on Merritt Island is a stop you must make – even if it is for a quick 30 minutes.

The Kennedy Space Center is a gateway to the wonders of space exploration and a testament to human achievement.

As NASA’s primary launch center, it has witnessed historic moments like the Apollo moon landings and Space Shuttle missions.

The center offers a blend of education and inspiration, allowing visitors to explore the past, present, and future of space travel.

From awe-inspiring rocket displays, like the Saturn V at the Apollo/Saturn V Center, to interactive exhibits and astronaut encounters, Kennedy Space Center offers an immersive journey into the cosmos.

Guided tours are also available from Orlando and Kissimmee.

Touring the Space Shuttle Atlantis exhibit and standing beneath colossal launch pads is definitely an experience that must not be missed!

4. Canaveral National Seashore, Titusville

Canaveral National Seashore near Titusville is a pristine coastal haven where nature’s beauty unfolds along untouched shores.

This protected reserve encompasses a diverse ecosystem of beautiful beaches, salt marshes, and mangrove forests, creating a sanctuary for wildlife and a serene escape for visitors.

Canaveral National Seashores provides nesting grounds for sea turtles and vital habitats for various bird species, making it a paradise for birdwatchers and nature enthusiasts.

With limited development, this is also one of the best places where you can experience the Sunshine State’s natural coastline in its purest form.

5. Heathcote Botanical Gardens, Fort Pierce

Heathcote Botanical Gardens in Fort Pierce is a tranquil oasis where the wonders of nature and art converge.

Spanning five acres, this enchanting garden showcases an array of lush landscapes, themed gardens, and carefully carved sculptures.

The James J. Smith Bonsai Collection, the Butterfly Garden, the Reflection Garden, and the Garden of Lights are all incredible spaces curated with patience and care, making Heathcote into the magical wonderland it is.

With its blend of botanical splendor, artistic expression, and a sense of tranquility, this hidden gem will truly rejuvenate your road trip spirit!

6. Fort Pierce Inlet State Park, Fort Pierce

Nestled along Florida’s stunning Atlantic coastline, Fort Pierce Inlet State Park offers a captivating blend of natural beauty and recreational opportunities.

Spanning over 340 acres, this is one of Florida’s premier state parks encompassing beautiful beaches, sand dunes, and diverse coastal habitats.

The park’s namesake inlet provides an ideal setting for fishing, boating, and observing marine life.

For history lovers, Fort Pierce Inlet State Park is also important as it was once the site of a World War II training camp.

7. West Palm Beach, Florida

West Palm Beach, is a coastal city seamlessly blending urban sophistication with natural beauty.

Nestled along the shores of the Atlantic Ocean, this vibrant destination has a lot to offer.

Downtown Clematis Street and Rosemary Square are always abuzz with live music, offering a variety of splendid dining, shopping, and entertainment options.

The Norton Museum of Art is also one of the best places for its dynamic blend of artistic genres, from European masterpieces of Monet and Picasso to contemporary creations.

The city’s cultural scene also thrives at venues like the Kravis Center for the Performing Arts.

With its blend of arts, live music, nature, and urban charm, West Palm Beach is a great place to rest, reenergize or even spend a night on your Florida Keys road trip!

8. Miami Beach

Miami Beach is a renowned coastal paradise that embodies the vibrant spirit of South Florida.

Nestled along the Atlantic Ocean, this iconic destination is celebrated for its pristine sandy shores, turquoise waters, and a captivating fusion of cultures.

The Art Deco Historic District, Ocean Drive, and Lummus Park are all the best places to admire the architecture, enjoy the nightlife and live music and slow down and watch the world go by!

The city’s cultural scene thrives with art galleries, museums, and live performances, and its diverse neighborhoods, from trendy South Beach to upscale Bal Harbour, offer a rich tapestry of experiences that are worth experiencing as a part of your Orlando to Key West road trip.

9. Skyviews Miami Observation Wheel, Miami

And while you’re passing through the Miami area, might as well stop by and experience the Skyviews Miami Observation Wheel!

This iconic attraction offers a breathtaking perspective of Miami’s skyline and coastal beauty.

Rising gracefully above Bayside Marketplace, with climate-controlled gondolas it’s a true delight to look at the shimmering waters of Biscayne Bay, and the city’s architectural wonders beyond it, including Downtown Miami – all from a bird’s eye view.

Whether day or night, the Skyviews Miami Observation Wheel offers the perfect opportunity to capture memorable photos, making it a special part of this epic Florida road trip from Orlando to Key West!

10. Everglades National Park, Miami

It is a widely known fact that the most exciting land-based popular activities in the famous Everglades National Park happen from the Miami side.

So while you are here, you might as well spend a night or two extra and make the Everglades an extended part of your epic journey, no?

Here, you can embark on a guided tour to glide through sawgrass prairies and encounter alligators, wading birds, and other wildlife.

Eco-adventurers can explore nature trails like Anhinga Trail, where herons and alligators share the spotlight.

This National Park is also a premier spot for birdwatchers.

Canoeing or kayaking through mangrove tunnels and waterways or taking a stroll along the Gumbo Limbo Trail are all popular activities to choose from!

11. Las Olas Boulevard, Fort Lauderdale

Once you have had enough of Miami, do not forget to make a pit stop at the iconic Las Olas Boulevard in Fort Lauderdale!

This vibrant and stylish destination combines upscale shopping, dining, and cultural experiences like live music, lined with chic boutiques, art galleries, and designer stores.

The boulevard also comes alive with an eclectic mix of international cuisines, ranging from fine dining to charming cafes, making it a culinary mecca for foodies as well!

12. Key Largo

And finally, it is time to hit Florida’s famous Keys!  But before you reach your destination of Key West, there are some other Key islands that might be worth exploring too.

Key Largo, the largest and northernmost of the Florida Keys, is best known as the “Diving Capital of the World”.

Its crystalline waters are a playground for snorkelers and scuba divers, offering mesmerizing encounters with vibrant coral reefs and marine life, especially around the John Pennekamp Coral Reef State Park – the world’s third-largest barrier reef!

Key Largo is an ideal setting especially if you are interested in water sports like snorkeling, scuba diving, kayaking, and paddleboarding.

13. Florida Barrier Reef

The Florida Barrier Reef, a hidden gem beneath the crystalline waters off the southeastern coast of Florida, is a stunning marine ecosystem.

Stretching along the Atlantic coastline, this lesser-known reef system is the only living coral reef in the continental United States!

Snorkelers and scuba divers are treated here to an enchanting world of color and movement, with coral gardens, shipwrecks, and underwater caves waiting to be explored.

So while you are on the scuba diving or snorkeling leg of this Florida Keys road trip, you might want to check out a guided tour of the Florida Barrier Reef as well!

14. Marathon Key

Marathon Key is best known for Sombrero Beach and its white sands invite sun-soaked days and leisurely picnics, while water sports like snorkeling, fishing, and kayaking abound.

The iconic Seven Mile Bridge connects Marathon Key to neighboring islands, providing panoramic views and a scenic drive or bike ride, making it just the most idyllic stopover on your journey right before the bustling scene at Key West’s Duval Street!

The West Coast route is a longer journey through Interstate 75, as compared to the East Coast route.

It’s a total distance of about 520 miles and takes around 8 to 9 hours to complete in a single stretch.

However, the west coast route is much quieter than the US-1 route and takes you through some mesmerizing countryside panoramic views of Big Cypress National Preserve and the Everglades National Park before finally merging onto US-1 at Palm Springs North.

And for that reason, it is definitely worth it to break your journey in parts and experience the beauty of Florida along the way!

The major cities and towns on the west coast route of the Orlando to Key West road trip include Tampa, Clearwater, St Petersburg, Sarasota, Fort Meyers, and Naples.

The Orlando to Key West road trip from the west coast route takes you through easily driveable, well-signposted highways.

Most of this route also has all basic amenities like gas stations, EV charging stations, hotels, and even a few campgrounds along the way.

Another upside of taking the east coast route is that there are no tolls along the way – only beautiful scenery!

1. Busch Gardens, Tampa

To start off your Orland to Key West road trip through the West Coast, why not visit Busch Gardens Tampa?

With over 300 acres of beautifully landscaped grounds, the park offers a unique fusion of adrenaline-pumping rides and captivating animal exhibits.

Visitors can experience world-class roller coasters like SheiKra and Montu, all the while contributing to Busch Gardens’ commitment to conservation and education.

Exhibits like the Serengeti Plain allow guests to observe exotic animals like giraffes and zebras in a habitat mimicking their natural environment.

Whether seeking high-speed adventure or a close encounter with fascinating creatures, adults and children alike can enjoy the well-rounded and exhilarating experience of Busch Gardens in Tampa.

2. Sawgrass Lake Park, St. Petersburg

On your next pit stop on this journey, consider Sawgrass Lake Park, situated in St. Petersburg.

This serene natural oasis invites visitors to immerse themselves in the beauty of Florida’s unique wetland ecosystem.

Spanning over 400 acres, with the expansive Sawgrass Lake as its centerpiece, the park is renowned for its sprawling sawgrass marshes, abundant wildlife, and diverse bird population.

An elevated boardwalk meanders through the heart of the park, offering a captivating opportunity to observe the intricate web of life that thrives in this pristine environment.

Whether birdwatching, hiking on nature trails, or simply enjoying the peaceful ambiance, visitors can connect with nature and escape the bustle of urban life at this hidden gem of the Sunshine State.

3. Sunshine Skyway Bridge, St. Petersburg

The Sunshine Skyway Bridge is an iconic and breathtaking feat of engineering that spans Tampa Bay, connecting St. Petersburg and Terra Ceia in Florida.

Stretching over 4 miles in length, this cable-stayed bridge is renowned for its stunning architectural design and panoramic views.

While on your road trip, this bridge will be a captivating part of your journey, providing sweeping vistas of the bay, the Gulf of Mexico, and the surrounding landscape!

4. Terra Ceia Aquatic Preserve

Located on the Gulf Coast, Terra Ceia Aquatic Preserve is a coastal gem encompassing over 24,000 acres of diverse marine and estuarine ecosystems.

This protected area, located 35 miles from Tampa, features lush mangrove forests, seagrass beds, and tidal flats, and is a vital habitat for various species of fish, birds, and other wildlife.

Boating, kayaking, fishing, and birdwatching are popular activities here, making for an adventurous, yet education-filled experience!

5. Siesta Key

Siesta Key, nestled on Florida’s Gulf Coast, is a renowned tropical paradise celebrated for its pristine beaches, soft white quartz sand, and crystal-clear turquoise waters.

This barrier island, located just southwest of Sarasota, offers a serene and idyllic escape for ocean lovers.

Siesta Beach has also been often proclaimed as the best beach in the United States.

Its powdery sand feels cool underfoot even on the sunniest days, making it a popular spot for relaxation, picnics, and water sports.

The island’s charming village boasts a vibrant arts scene, eclectic shops, and a variety of breakfast and dining options.

This is a great destination for kayaking, paddleboarding, and exploring its mangrove-lined waterways.

Nature preserves like Point of Rocks provide a glimpse into the area’s diverse ecosystem, while the Siesta Key Drum Circle captures the island’s laid-back and creative spirit, making it a great place to spend some time while on your Orlando to Key West journey through the west coast!

6. Edison & Ford Winter Estates, Fort Myers

The Edison and Ford Winter Estates, located in Fort Myers, are a historical treasure that pays tribute to the ingenuity and creativity of two of America’s greatest inventors, Thomas Edison and Henry Ford.

The estates encompass beautifully preserved homes, lush gardens, and a museum, offering a glimpse into the lives and accomplishments of these remarkable men.

Thomas Edison’s home, laboratory, and botanical research gardens reflect his innovative spirit and contributions to technology and science.

Henry Ford’s winter retreat, neighboring Edison’s estate, showcases his passion for invention and industry.

The estates provide an immersive experience, featuring a guided tour that delves into the inventors’ legacies and the era they lived in.

This is a great stop on your Key West road trip, for some inspiring travel back in time!

7. Sanibel Island

Sanibel Island, nestled on Florida’s Gulf Coast, is a tranquil haven celebrated for its unspoiled natural beauty and pristine beaches.

Renowned for its unique east-west orientation, Sanibel’s shores are a treasure trove of seashells, attracting beachcombers and collectors from around the world, especially to the famous Bowman’s Beach.

The island is a sanctuary for wildlife, with the J.N. “Ding” Darling National Wildlife Refuge providing a vital habitat for birds, reptiles, and marine life.

Nature enthusiasts will love its mangrove estuaries and wetlands through kayaking and wildlife watching.

For a peep in history, visit the Sanibel Historical Museum and Village offering a glimpse into the island’s past, while the Sanibel Lighthouse stands as a beacon of maritime history.

8. Tamiami Trail, Big Cypress National Park

The Tamiami Trail, a scenic highway connecting Tampa to Miami in Florida, traverses through the heart of the Big Cypress National Preserve, offering travelers a captivating journey through a unique and diverse wilderness.

This ecologically significant region encompasses over 700,000 acres of swamps, hardwood hammocks, and cypress forests, providing a vital habitat for an array of wildlife.

The Tamiami Trail is a gateway to the Big Cypress National Preserve which is home to a rich variety of flora and fauna, including elusive Florida panthers and wading birds.

Outdoor enthusiasts can explore the preserve through nature trails, birdwatching, and wildlife photography.

9. Ten Thousand Islands, Everglades National Park

The Ten Thousand Islands, a mesmerizing labyrinth of mangrove islands and waterways along Florida’s Gulf Coast, form a unique and enchanting natural wonder.

This sprawling expanse of estuaries, bays, and channels is a haven for biodiversity, harboring a rich tapestry of marine and avian life,  including wading birds, eagles, roseate spoonbills, and bottlenose dolphins and manatees, and thriving in its shallow waters.

Nestled within the Everglades ecosystem, the Ten Thousand Islands offer a glimpse into an unspoiled wilderness.

Exploring the Ten Thousand Islands reveals hidden coves, beautiful beaches, and serene water trails, accessible by kayak, canoe, or boat.

This is a great stop that absolutely must not be missed on your Orland to Key West journey through the West Coast!

10. Bahia Honda State Park

Once you finally enter the Florida Keys, Bahia Honda State Park should be your first stop!

This is one of the best state parks in Florida, known for its beautiful beaches, crystal-clear waters, and diverse marine life, boasts some of the most picturesque with powdery white sand and vibrant turquoise blues in the region.

The historic Bahia Honda Rail Bridge, a remnant of the Overseas Railroad, adds a touch of nostalgia and also serves as a unique vantage point for the park’s panoramic views.

You can hike through nature trails, spotting native plants and wildlife, or engage in water sports and popular activities like kayaking and paddleboarding.

This state park’s underwater wonders also make it a prime spot for water sports like snorkeling and scuba diving, revealing a vibrant underwater world teeming with coral reefs and marine creatures.

11. Southernmost Point, Key West

Finally, when you arrive at your much-awaited destination, Key West, a visit to the southernmost point in the continental United States is a must.

This famous painted buoy, brightly adorned with colorful markings, perched just a mere 90 miles from Cuba, offers not only a geographical distinction but also a sense of connection to the broader Caribbean region.

Tourists flock to this spot to take photographs and soak in the panoramic views of the ocean.

So beware – this great place might be more crowded than you expected!

While the buoy itself is a popular attraction, the Southernmost Point is also surrounded by nearby attractions, shops, and restaurants adding to the lively atmosphere.

Orlando To Key West Road Trip: Things To Keep In Mind

✓ The best time to visit Florida is during the shoulder seasons (spring and fall) when the weather is mild and the crowds are smaller.

✓ Make sure to book your accommodations in advance, especially if you’re traveling during peak season.

✓ Pack plenty of sunscreen, insect repellent, and water.

✓ Allow plenty of time for great stops along the way. Having a flexible schedule is the way to go!

✓ The Florida Keys are a chain of islands, so you’ll need to take a ferry to get to Key West.

✓ The famous Overseas Highway is a scenic route that connects the Keys, but it can be slow-going due to the many bridges.

Orlando To Key West Road Trip: Frequently Asked Questions

Where Should I Stop Between Orlando And Key West?

Traveling between Orlando and Key West offers a variety of great stops to break up the journey and explore different attractions along the way.

Some of these places that are worth checking out include West Palm Beach, Fort Lauderdale, Miami, Key Largo, and Marathon Key.

And once you are in the Keys, do not forget to try the iconic Key lime pie!

How Long Does It Take To Drive From Orlando To The Keys?

The driving distance from Orlando to Key West is approximately 400 miles along the west coast route.

On average, this drive can take around 6 to 8 hours if you are driving without any major stops.

Is It Worth Driving All The Way To Key West?

Driving all the way to Key West from Orlando can be a rewarding and memorable experience, and is definitely worth it because it offers scenic routes such as the famous Overseas Highway and unique stops at charming towns.

Other reasons to visit Key West include its decadent Key lime pie, sunsets over Mallory Square, and the iconic Duval Street!

Is The Drive To Key West Beautiful?

Yes, the drive from the sunshine state of mainland Florida to Key West is renowned for its exceptional beauty and unique charm.

The drive offers stunning coastal scenery, picturesque panoramic views, and the experience of traveling across a series of bridges and causeways that connect the islands of the Florida Keys.

You also have the opportunity to see the mesmerizing turquoise waters of the Atlantic Ocean and the Gulf of Mexico on either side.

Additionally, the drive is dotted with small towns, parks, and opportunities for sightseeing, making it more than just a means of transportation – it’s an experience in itself!